DPP8 蛋白, Human (Sf9, His)

The DPP8 protein cleaves N-terminal dipeptides from proteins with Pro or Ala at position 2. DPP8 Protein, Human (Sf9, His) is the recombinant human-derived DPP8 protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of DPP8 Protein, Human (Sf9, His) is 898 a.a., .

DPP8 蛋白作为二肽基肽酶发挥作用，从 2 位含有 Pro 或 Ala 残基的蛋白质中裂解 N 端二肽。它通过防止静息细胞中 caspase-1 依赖性单核细胞和巨噬细胞焦亡的关键抑制剂发挥着至关重要的作用。NLRP1 和 CARD8 的激活。DPP8 通过将 NLRP1 和 CARD8 的切割 C 端部分（它们各自炎症小体的活性成分）隔离在三元复合物中来实现这一点，从而阻止它们的寡聚化和随后的激活。DPP8 的二肽基肽酶活性对于抑制 NLRP1 和 CARD8 至关重要，尽管这两种蛋白质似乎都不是 DPP8 的直接底物。这表明存在抑制 NLRP1 和 CARD8 所需的未识别底物，突出了 DPP8 在细胞焦亡和炎性体激活背景下精心策划的复杂调节机制。

Human

Sf9 insect cells

N-8*His

Q6V1X1 (M1-I898)

54878

105.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 200 mM NaCl, 20% glycerol, 1 mM DTT, pH 7.5.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.