DSC2/Desmocollin-2 蛋白, Human (HEK293, C-His)

DSC2/Desmocollin-2 protein is vital for intercellular desmosome junctions, mediating adhesion by interacting with plaque proteins and intermediate filaments. It also regulates cell positioning and interacts with DSP, PKP2, and JUP, strengthening junction stability. Overall, DSC2/Desmocollin-2 protein maintains tissue organization and functionality. DSC2/Desmocollin-2 Protein, Human (HEK293, C-His) is the recombinant human-derived DSC2/Desmocollin-2, expressed by HEK293 , with C-10*His labeled tag. The total length of DSC2/Desmocollin-2 Protein, Human (HEK293, C-His) is 657 a.a.,

DSC2/Desmocollin-2 蛋白是细胞间桥粒连接的关键成分，通过介导斑块蛋白和中间丝之间的相互作用，在促进细胞间粘附方面发挥着至关重要的作用。除了其粘附功能外，DSC2 还可能通过调节表达不同亚型的细胞之间的粘附性来促进表皮细胞定位。该蛋白与 DSP、PKP2 和 JUP 相互作用，进一步增强这些连接的稳定性和完整性。通过参与这些分子相互作用，DSC2/Desmocollin-2 蛋白确保组织的正确组织和功能。

Measured by its ability to inhibit the proliferation of PC-3 cells. The ED₅₀ for this effect is 0.8445 μg/mL, corresponding to a specific activity is 1184.13 units/mg.

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  Measured by its ability to inhibit the proliferation of PC-3 cells. The ED₅₀ for this effect is 0.8445 μg/mL, corresponding to a specific activity is 1184.13 units/mg.

Human

HEK293

C-10*His

Q02487 (A28-R684)

1824

ASDACKNVTLHVPSKLDAEKLVGRVNLKECFTAANLIHSSDPDFQILEDGSVYTTNTILLSSEKRSFTILLSNTENQEKKKIFVFLEHQTKVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQNYTIYYSIRGPGVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELPLPLIIKIEDENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHTRLKYSIIGQVPPSPTLFSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNSPFIPKKTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPR

Approximately 80-100 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.