EDAR 蛋白, Mouse (HEK293, Fc)

EDAR protein is a receptor for the EDA isoform TAA, which, unlike TA-2, may activate the NF-kappa-B and JNK pathways, indicating its involvement in immune signaling. In addition, EDAR may cause caspase-independent cell death. EDAR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EDAR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of EDAR Protein, Mouse (HEK293, Fc) is 163 a.a., with molecular weight of 58-74 kDa.

EDAR 蛋白作为 EDA 同工型 TAA 的受体，使其与同工型 TA-2 区分开来。该受体可能介导 NF-kappa-B 和 JNK 通路的激活，表明其参与与免疫反应相关的信号级联反应。此外，EDAR 可能在促进不依赖 caspase 的细胞死亡中发挥作用。它与 EDARADD 的结合以及与 TRAF1、TRAF2、TRAF3 和 NIK 等关键蛋白的关联强调了它在复杂信号网络中的作用，强调了它在免疫调节之外的细胞过程中的重要性，可能有助于细胞存活和程序性细胞死亡机制。

Mouse

HEK293

C-hFc

Q9R187 (E27-I189)

13608  [NCBI]

EDSNCGENEYHNQTTGLCQQCPPCRPGEEPYMSCGYGTKDDDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGVSAHSSSTSGGSTLSPFQHAHKELSGQGHLATALI

58-74 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.