EDNRB/Endothelin R Type B 蛋白, Human (HEK293, His)

EDNRB/Endothelin R Type B Protein, a non-specific receptor for endothelin 1, 2, and 3, activates a phosphatidylinositol-calcium second messenger system through G proteins. This mechanism underscores its pivotal role in mediating cellular responses initiated by endothelin neuropeptides, emphasizing the versatility of EDNRB in transducing signals for various physiological processes. EDNRB/Endothelin R Type B Protein, Human (HEK293, His) is the recombinant human-derived EDNRB/Endothelin R Type B protein, expressed by HEK293 , with C-His labeled tag.

EDNRB/内皮素 R B 型蛋白是内皮素 1、2 和 3 的非特异性受体，通过与 G 蛋白结合来激活磷脂酰肌醇-钙第二信使系统。这种分子相互作用机制强调了其在介导内皮素神经肽引发的细胞反应中的关键作用，强调了 EDNRB 在转导有助于各种生理过程的信号方面的多功能性。

Measured by its binding ability in a functional ELISA. Immobilized Human EDNRB, at 5 μg/mL (100 μL/well) can bind Anti-EDNRB antibody. The ED₅₀ for this effect is 1.836 ng/mL.

Human

HEK293

C-6*His

P24530/NP_000106.1 (E27-K101)

1910  [NCBI]

EERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFK

Approximately 16-33 kDa due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.