Enterotoxin type A 蛋白, S. aureus (His)

Enterotoxins (ETAs) trigger host immune system activation by binding to major histocompatibility complex class II and T-cell receptor (TCR) molecules. This interaction triggers a cascade of cell activation, cytokine production and migration, primarily mediated by Alphata T cells, affecting lung tissue and airways. Enterotoxin type A Protein, S. aureus (His) is the recombinant Staphylococcus aureus-derived Enterotoxin type A protein, expressed by E. coli , with N-6*His labeled tag. The total length of Enterotoxin type A Protein, S. aureus (His) is 233 a.a., with molecular weight of ~28 kDa.

A 型肠毒素 (ETA) 是一种葡萄球菌肠毒素，通过以未加工形式与主要组织相容性复合物 II 类和 T 细胞受体 (TCR) 分子结合来激活宿主免疫系统。这种相互作用引发了一系列涉及细胞激活、细胞因子产生和迁移波的事件，这些事件主要由 Alphata T 细胞介导，最终影响肺组织和气道。此外，ETA 还与葡萄球菌食物中毒综合征的发生有关，该综合征的症状包括高烧、低血压、腹泻、休克，严重时可能导致死亡。

Staphylococcus aureus

E. coli

N-6*His

P0A0L2 (S25-S257)

/

SEKSEEINEKDLRKKSELQGTALGNLKQIYYYNEKAKTENKESHDQFLQHTILFKGFFTDHSWYNDLLVDFDSKDIVDKYKGKKVDLYGAYYGYQCAGGTPNKTACMYGGVTLHDNNRLTEEKKVPINLWLDGKQNTVPLETVKTNKKNVTVQELDLQARRYLQEKYNLYNSDVFDGKVQRGLIVFHTSTEPSVNYDLFGAQGQYSNTLLRIYRDNKTINSENMHIDIYLYTS

Approximately 28 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, 5% trehalose, 5% mannitol and 0.01% Tween80, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.