1. 重组蛋白
  2. Viral Proteins
  3. Bacterial/Fungal Proteins
  4. Enterotoxin type H 蛋白, S. aureus (P.pastoris, His)

Enterotoxin type H 蛋白, S. aureus (P.pastoris, His)

目录号: HY-P71807
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肠毒素 (ETH) 通过作为原始分子与主要组织相容性复合物 II 类和 T 细胞受体 (TCR) 分子结合(特别是通过其 α 结构域,特别是 TRAV27)来激活宿主免疫系统。这种相互作用形成三元复合物,激活大量 T 淋巴细胞并引发促炎细胞因子的广泛释放。Enterotoxin type H 蛋白, S. aureus (P.pastoris, His) 是重组的 H 型肠毒素蛋白,由 P. pastoris 表达,带有 N-His 标签。

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描述

Enterotoxin (ETH) activates the host immune system by binding as a raw molecule to major histocompatibility complex class II and T-cell receptor (TCR) molecules, specifically through its alpha domain, specifically TRAV27 . This interaction forms a ternary complex that activates a large number of T lymphocytes and triggers the widespread release of proinflammatory cytokines. Enterotoxin type H Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Enterotoxin type H protein, expressed by P. pastoris , with N-His labeled tag.

研究背景

H 型肠毒素 (ETH) 是一种葡萄球菌肠毒素,通过作为未加工的分子与主要组织相容性复合物 II 类和 T 细胞受体 (TCR) 分子结合(特别是通过其 α 结构域,特别是 TRAV27)来激活宿主免疫系统。这种相互作用形成三元复合物,进而触发大量 T 淋巴细胞的激活,引发促炎细胞因子的广泛释放。此外,ETH 还与葡萄球菌食物中毒综合征的发生有关,这种疾病的症状包括高烧、低血压、腹泻、休克,严重时可能导致死亡。

种属

Staphylococcus aureus

表达系统

P. pastoris

标签

N-His

蛋白编号

P0A0M0 (E25-V241)

基因 ID

/

蛋白结构
N-term
His
SHE (E25-V241)
Accession # P0A0M0
C-term
中文名
Enterotoxin type H 蛋白
同用名
entH; sehEnterotoxin type H; SEH
氨基酸序列

EDLHDKSELTDLALANAYGQYNHPFIKENIKSDEISGEKDLIFRNQGDSGNDLRVKFATADLAQKFKNKNVDIYGASFYYKCEKISENISECLYGGTTLNSEKLAQERVIGANVWVDGIQKETELIRTNKKNVTLQELDIKIRKILSDKYKIYYKDSEISKGLIEFDMKTPRDYSFDIYDLKGENDYEIDKIYEDNKTLKSDDISHIDVNLYTKKKV

分子量

Approximately 27.1 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Enterotoxin type H Protein, S. aureus (P.pastoris, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Enterotoxin type H Protein, S. aureus (P.pastoris, His)
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HY-P71807
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