2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. Eotaxin/CCL11
  7. Eotaxin/CCL11 蛋白, Human (His)

Eotaxin/CCL11 蛋白, Human (His)

目录号: HY-P700963
产品使用指南

Eotaxin/CCL11 蛋白积极促进嗜酸性粒细胞积累以应对过敏原，这是过敏性炎症的一个显着特征，强调了其在过敏期间免疫反应协调中的关键作用。这种调节功能是通过与 CCR3 受体结合来实现的，强调了其与细胞受体的特异性相互作用，以调节嗜酸性粒细胞迁移和激活以响应过敏刺激。Eotaxin/CCL11 蛋白, Human (His) 是重组的 嗜酸细胞活化趋化因子/CCL11 蛋白，由 E. coli 表达，带有 N-His 标签。Eotaxin/CCL11 蛋白, Human (His) 全长 74 个氨基酸，分子量为 13-15 kDa。

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描述

Eotaxin/CCL11 Protein actively promotes eosinophil accumulation in response to allergens, a distinctive feature of allergic inflammation, emphasizing its pivotal role in immune response orchestration during allergies. This regulatory function is achieved through binding to the CCR3 receptor, underscoring its specific interaction with cellular receptors to modulate eosinophil migration and activation in response to allergenic stimuli. Eotaxin/CCL11 Protein, Human (His) is the recombinant human-derived Eotaxin/CCL11 protein, expressed by E. coli , with N-His labeled tag. The total length of Eotaxin/CCL11 Protein, Human (His) is 74 a.a., with molecular weight of 13-15 kDa.
研究背景

为了应对过敏原的存在，嗜酸性粒细胞活化趋化因子/CCL11 蛋白积极促进嗜酸性粒细胞的积累，这是过敏性炎症反应的独特标志。这种效应在科学文献中有详细记载，强调了该蛋白质在过敏过程中协调免疫反应的关键作用。值得注意的是，Eotaxin/CCL11 通过与 CCR3 受体结合来实现这种调节功能，强调其与细胞受体的特异性相互作用，调节嗜酸性粒细胞响应过敏刺激的迁移和激活。
种属

Human
表达系统

E. coli
标签

N-His
蛋白编号

P51671 (G24-P97)
基因 ID
蛋白结构
N-term
His
CCL11 (G24-P97)
Accession # P51671
C-term
同用名
Eotaxin; C-C motif chemokine 11; Small-inducible cytokine A11; SCYA11; eotaxin-1
分子量

13-15 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Eotaxin/CCL11 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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