Ephrin-A3/EFNA3 蛋白, Human (HEK293)

Ephrin-A3/EFNA3 proteins are cell surface GPI-binding ligands of Eph receptors and play a key role in regulating key cellular processes such as migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. As a promiscuous binder, Ephrin-A3 binds to Eph receptors on neighboring cells, initiating contact-dependent bidirectional signaling to neighboring cells. Ephrin-A3/EFNA3 Protein, Human (HEK293) is the recombinant human-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with tag free. The total length of Ephrin-A3/EFNA3 Protein, Human (HEK293) is 191 a.a., with molecular weight of 35-40 kDa.

Ephrin-A3 (EFNA3) 是一种细胞表面糖基磷脂酰肌醇 (GPI) 结合配体，在发育过程中的细胞相互作用中发挥着关键作用。它属于 Eph 受体家族，这是一组对神经元、血管和上皮组织中的迁移、排斥和粘附等过程至关重要的受体酪氨酸激酶。EFNA3 表现出与邻近细胞上的 Eph 受体的混杂结合，启动接触依赖性双向信号传导至邻近细胞。这种双向信号传导涉及受体下游的正向信号传导通路和肝配蛋白配体下游的反向信号传导通路。此外，EFNA3 与 EPHA8 特异性相互作用，激活受体并促进下游信号传导事件。

Measured by its ability to bind biotinylated mouse EPHA6-Fc in a functional ELISA.

Human

HEK293

Tag Free

P52797 (Q23-S213)

1944  [NCBI]

QGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSIS

35-40 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.