Epiregulin 蛋白, Mouse (HEK293, hFc)

Epiregulin Protein, a ligand for EGFR and ERBB4, induces their tyrosine phosphorylation, playing a pivotal role in inflammation, wound healing, tissue repair, and oocyte maturation. It regulates angiogenesis, vascular remodeling, and cell proliferation, emphasizing its involvement in intricate cellular signaling pathways. Epiregulin Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived Epiregulin protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Epiregulin Protein, Mouse (HEK293, hFc) is 46 a.a., with molecular weight of ~37 kDa.

上皮调节蛋白作为 EGF 受体 (EGFR) 和 ERBB4 的配体，引发这些受体的酪氨酸磷酸化。这种多功能蛋白质在各种生理过程中发挥着关键作用，包括炎症、伤口愈合、组织修复和卵母细胞成熟，通过调节血管生成、血管重塑和细胞增殖发挥影响。它与 EGFR 和 ERBB4 的相互作用凸显了它参与复杂的细胞信号传导途径。

Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells and the ED₅₀ is typically 0.5-2.5 μg/mL.

Mouse

HEK293

N-hFc

Q61521 (V56-L101)

13874  [NCBI]

Approximately 37 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.