1. 重组蛋白
  2. Fc Receptors Biotinylated Proteins
  3. Fc-gamma Receptor
  4. Fc gamma RIII/CD16
  5. Fc gamma RIII/CD16 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

Fc gamma RIII/CD16 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

目录号: HY-P76207
产品使用指南

Fc gamma RIII/CD16 蛋白是 IgG1、IgG2a 和 IgG2b 的低亲和力受体,对于介导中性粒细胞响应 IgG 复合物的激活至关重要。它与 Fcgr4 冗余地发挥作用,并与 INPP5D/SHIP1 相互作用,强调其参与与免疫反应相关的细胞内信号传导途径。Fc gamma RIII/CD16 的重要性在于促进免疫球蛋白结合触发的细胞激活。Fc gamma RIII/CD16 蛋白, Mouse (Biotinylated, HEK293, His-Avi) 是重组的 Fc gamma RIII/CD16 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。

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描述

Fc gamma RIII/CD16 Protein, a low-affinity receptor for IgG1, IgG2a, and IgG2b, is crucial for mediating neutrophil activation in response to IgG complexes. It functions redundantly with Fcgr4 and interacts with INPP5D/SHIP1, emphasizing its involvement in intracellular signaling pathways linked to immune responses. Fc gamma RIII/CD16's significance lies in facilitating cellular activation triggered by immunoglobulin binding. Fc gamma RIII/CD16 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived Fc gamma RIII/CD16 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

研究背景

Fc gamma RIII/CD16 蛋白作为复合免疫球蛋白 gamma Fc 区的低亲和力受体,特异性结合 IgG1、IgG2a 和 IgG2b。该受体在介导中性粒细胞响应 IgG 复合物的激活中发挥着至关重要的作用,在此过程中与 Fcgr4 一起发挥冗余作用。与 INPP5D/SHIP1 的相互作用进一步凸显了其参与与免疫反应相关的细胞内信号通路,强调了其在促进免疫球蛋白结合触发的细胞激活中的重要性。

种属

Mouse

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

P08508 (A31-T215)

基因 ID

14131  [NCBI]

蛋白结构
N-term
Fc gamma RIII/CD16 (A31-T215)
Accession # P08508
Avi-His
C-term
同用名
Low affinity immunoglobulin gamma Fc region receptor III; Fcgr3; Fc gamma Receptor III; CD-antigen 16; CD16; FcRIII; IgG Fc receptor III
分子量

Approximately 24.4 kDa.

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Fc gamma RIII/CD16 Protein, Mouse (Biotinylated, HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Fc gamma RIII/CD16 Protein, Mouse (Biotinylated, HEK293, His-Avi)
目录号:
HY-P76207
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