FCGRT-B2M Heterodimer 蛋白, Cynomolgus (Biotinylated, HEK293, His)

The FCGRT protein transfers passive immunity by binding to monomeric IgG and facilitating its uptake from milk. It forms FcRn-IgG complexes that are transcytosed across the intestinal epithelium, releasing IgG into the bloodstream or tissue fluids. This receptor also recycles IgG, prolonging its half-life in circulation. Mechanistically, it binds to monomeric IgG in acidic endosomes, enabling recycling to the cell surface. The FCGRT-B2M heterodimer also regulates albumin homeostasis and consists of p51 and p14 subunits. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing cynomolgus-derived FCGRT-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Cynomolgus (Biotinylated, HEK293, His), has molecular weight of ~31.9 & 11.6 KDa, respectively.

FCGRT 蛋白是一种细胞表面受体，在将被动体液免疫从母亲转移到新生儿方面发挥着关键作用。它通过与单体免疫球蛋白 γ 的 Fc 区结合并促进其从牛奶中选择性摄取来实现这一点。在肠上皮内，FCGRT-B2M 异二聚体在顶端表面与 IgG 结合，形成 FcRn-IgG 复合物，该复合物在上皮中转胞吞，将 IgG 释放到血流或组织液中。该受体通过回收 IgG 并延长其在循环中的半衰期，在整个生命周期中持续促进有效的体液免疫。从机制上讲，单体 IgG 与内皮细胞和造血细胞酸性内体中的 FCGRT-B2M 结合，使 IgG 能够循环到细胞表面，并释放到循环中。此外，FCGRT-B2M 异二聚体通过与白蛋白（最丰富的循环蛋白）相互作用，在调节白蛋白的稳态中发挥作用。FCGRT-B2M 复合物由两个亚基 p51 和 p14（相当于 β-2-微球蛋白）组成，形成 MHC I 类异二聚体。

Cynomolgus

HEK293

C-His

Q8SPV9 (A24-S297)&Q8SPW0 (I21-M119)

102128913  [NCBI]&101867173  [NCBI]

Approximately 31.9&11.6 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.