FCGRT-B2M Heterodimer 蛋白, Human (HEK293, His)

The FCGRT protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. It binds IgG at the intestinal epithelium and forms an FcRn-IgG complex that is transcytosed across the epithelium, releasing IgG into the blood or tissue. FCGRT-B2M Heterodimer Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Human (HEK293, His), has molecular weight of ~35 & 12 kDa, respectively.

FCGRT 是一种重要的细胞表面受体，通过与单体免疫球蛋白 γ 的 Fc 区结合并选择性介导其从乳汁中的摄取，促进被动体液免疫从母亲转移到新生儿。该过程涉及 IgG 在肠上皮顶端表面结合，形成 FcRn-IgG 复合物，通过肠上皮转胞吞，将 IgG 释放到血液或组织液中。在婴儿期之后，FCGRT 通过回收 IgG 并延长其在循环中的半衰期，在有效的体液免疫中发挥着关键作用。从机制上讲，单体 IgG 与内皮细胞和造血细胞酸性内体中的 FCGRT 结合，促进 IgG 循环到细胞表面，随后将其释放到循环中。此外，FCGRT 调节白蛋白/ALB（另一种最丰富的循环蛋白）的稳态，进一步强调了其在免疫和蛋白质稳态中的重要作用。在微生物感染的情况下，FCGRT 充当各种埃可病毒的脱衣受体，包括埃可病毒 5、6、7、9、11、13、25 和 29。

Measured by its ability to bind human IgG1 in a functional ELISA.

Human

HEK293

C-His

P55899 (A24-S297)&P61769 (I21-M119)

2217  [NCBI]&567

Approximately 35&12 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.