FCGRT-B2M Heterodimer 蛋白, Rat (HEK293, C-His)

The FCGRT-B2M heterodimeric protein is a cell surface receptor that interacts with IgG and albumin and contributes to effective humoral immunity. FCGRT-B2M Heterodimer Protein, Rat (HEK293, C-His) is a recombinant protein dimer complex containing rat-derived FCGRT-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. FCGRT-B2M Heterodimer Protein, Rat (HEK293, C-His), has molecular weight of ~38-55 & 12 kDa, respectively.

FCGRT-B2M 异二聚体蛋白作为重要的细胞表面受体，促进被动体液免疫从母亲转移到新生儿。它识别单体免疫球蛋白 γ 的 Fc 区，选择性地从牛奶中摄取 IgG，特别是在肠上皮的顶端表面。形成的 FcRn-IgG 复合物穿过肠上皮进行转胞吞作用，将 IgG 从 FcRn 释放到血液或组织液中。该过程通过回收 IgG 并延长其在循环中的半衰期，对有效的体液免疫做出了重大贡献。从机制上讲，单体 IgG 与内皮细胞和造血细胞酸性内体中的 FcRn 结合，促进 IgG 循环到细胞表面，将其释放到循环中。值得注意的是，除了在 IgG 稳态中发挥作用外，FCGRT-B2M 异二聚体还通过与白蛋白相互作用调节另一种丰富的循环蛋白白蛋白/ALB 的稳态。FcRn 复合物由两个亚基 p51 和 p14（相当于 β-2-微球蛋白）组成，形成 MHC I 类异二聚体，突出了其在免疫和蛋白质稳态中的关键作用。

Measured by its binding ability in a functional ELISA. When FCRN-B2M is immobilized at 2 µg/mL (100 µL/well), can bind Biotinylated Human lgG1. The ED₅₀ for this effect is 109.3 ng/mL.

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  Measured by its binding ability in a functional ELISA. When FCRN-B2M is immobilized at 2 µg/mL (100 µL/well), can bind Biotinylated Human lgG1, the ED₅₀ for this effect is 109.3 ng/mL.

Rat

HEK293

C-His

P13599 (A23-S298)&P07151 (I21-M119)

29558&24223

Approximately 38-55 & 12 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.