Fetuin A/AHSG 蛋白, Macaca mulatta (HEK293, His)

Fetuin A/AHSG Protein is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. Fetuin A is a plasma carrier protein that helps to transport and make a wide range of substances available in the bloodstream. Fetuin A is a hepatokine which has the capacity to prevent vascular calcification. Fetuin A is a multifunctional protein that plays important roles in diabetes, kidney disease, and cancer, as well as in inhibition of ectopic calcification^[1][2][3]. Fetuin A/AHSG Protein, Macaca mulatta (HEK293, His) is the recombinant Fetuin A/AHSG protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Fetuin A/AHSG Protein, Macaca mulatta (HEK293, His) is 349 a.a., with molecular weight of ~50.4 kDa.

Fetuin A 的分子量范围为 51 至 67 kDa，具体取决于糖基化程度。它是一种带负电荷的糖蛋白，在血液和细胞外液中循环，半衰期为数天^[1]。
Fetuin A 是一种肝分泌糖蛋白，通过抑制骨骼肌和肝细胞中的胰岛素受体酪氨酸激酶来促进胰岛素抵抗，作为饱和脂肪酸的衔接蛋白并允许它们激活 Toll 样受体 4 (TLR4) ，从而诱导炎症信号传导和胰岛素抵抗。Fetuin A 通过结合小簇钙和磷酸盐来抑制软组织钙化。Fetuin A  增强血管平滑肌细胞和巨噬细胞对细胞外囊泡和凋亡细胞的吞噬作用，减少细胞外矿物质离子浓度升高的细胞的凋亡和钙化^[1]。
Fetuin A 与多种受体结合，表现出多方面的生理和病理功能。它参与钙代谢、成骨和胰岛素信号通路的调节。它还具有异位钙化抑制剂、蛋白酶抑制剂、炎症介质、抗炎伴侣、动脉粥样硬化因子和脂肪形成因子等多种兼职功能^[2]。

Others

HEK293

C-10*His

A0A2K6AQI2 (A19-V367)

105480162  [NCBI]

APHGPGLIYRQPNCDDPETEEAALVAVDYINQNLPWGYKHTLNQIDEVKVWPQQPFGEMFEIEIDTLETTCHVLDPTPVAGCRVRQLKEHAVEGDCDFQLLKVNGKFSVEYAKCDSSPDSAEDVRKVCRDCPLLAPLNDTRVVHAAEAAVTAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTISGTDCVAKEATEAANCNLLAKKQYGFCKATLNEKLGGEEVAVTCTVFQTQPATSQPQPEGANEAVPTPVVDADAPASYPVGASGPLPTGSPIYAHVLAAAPPVVPIHSSHYDLRHLFMGVVSLRSPSGEALHPRKTRSVVQPSVGAAAGPVVPPCPGRVRHFKV

Approximately 50.4 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.