FGF-15 蛋白, Mouse (His-SUMO)

FGF-15 Protein crucially suppresses bile acid biosynthesis by down-regulating CYP7A1 expression, contributing to intricate bile acid homeostasis control. Interacting with MALRD1 suggests potential involvement in molecular pathways beyond bile acid regulation. The molecular associations and regulatory functions underscore FGF-15's significance in maintaining physiological balance, particularly in bile acid metabolism. FGF-15 Protein, Mouse (His-SUMO) is the recombinant mouse-derived FGF-15 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of FGF-15 Protein, Mouse (His-SUMO) is 193 a.a., with molecular weight of ~38 kDa.

FGF-15 蛋白通过下调 CYP7A1 表达，在抑制胆汁酸生物合成中发挥至关重要的作用。通过其调节活性，FGF-15 有助于胆汁酸稳态的复杂控制。此外，该蛋白与 MALRD1 相互作用，表明其可能参与胆汁酸调节以外的分子途径和过程。FGF-15 的分子关联和调节功能凸显了其在维持生理平衡方面的重要性，特别是在胆汁酸代谢方面。

Mouse

E. coli

N-His;N-SUMO

O35622 (R26-K218)

14170  [NCBI]

RPLAQQSQSVSDEDPLFLYGWGKITRLQYLYSAGPYVSNCFLRIRSDGSVDCEEDQNERNLLEFRAVALKTIAIKDVSSVRYLCMSADGKIYGLIRYSEEDCTFREEMDCLGYNQYRSMKHHLHIIFIQAKPREQLQDQKPSNFIPVFHRSFFETGDQLRSKMFSLPLESDSMDPFRMVEDVDHLVKSPSFQK

Approximately 38 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in PBS, 6% Trehalose, pH 7.4 or 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.