FGF-16 蛋白, Human (CHO)

FGF-16 Protein, Human (CHO) is a polypeptide chain containing 206 amino acids produced in CHO cells. FGF-16 is a heparin binding growth factor, a member of the FGF family.

成纤维细胞生长因子-16 (FGF-16) 是一种肝素结合生长因子，是 FGF 家族的成员。所有 FGF 家族成员都是肝素结合生长因子，具有 120 个氨基酸 (aa) 核心 FGF 结构域，可实现共同的三级结构。FGF家族成员具有广泛的有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。大鼠同源物主要在胚胎棕色脂肪组织中表达，具有显着的促有丝分裂活性，这表明其在胚胎棕色脂肪组织的增殖中发挥作用^[1]。

The ED₅₀ is <20 ng/mL as measured by 3T3 mouse fibroblast cell, corresponding to a specific activity of >2 × 10⁴ units/mg.

Human

CHO

Tag Free

O43320 (A2-R207)

8823  [NCBI]

AEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR

Approximately 23 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Wang J, et al. Cardiac Fgf-16 Expression Supports Cardiomyocyte Survival and Increases Resistance to Doxorubicin Cytotoxicity. DNA Cell Biol. 2018 Nov;37(11):866-877.  [Content Brief]