FGF basic/bFGF 蛋白, Bovine (His)

FGF2 protein is a multifunctional ligand that can bind to FGFR1, FGFR2, FGFR3 and FGFR4. It is also a key integrin ligand for FGF2 signal transduction and has an important interaction with the integrin ITGAV:ITGB3. FGF2 plays a critical role in cell survival, division, differentiation, and migration, serves as a potent mitogen, and induces angiogenesis. FFGF basic/bFGF protein, Bovine (His)) is the recombinant bovine-derived FGF2 protein, expressed by E. coli , with N-6*His labeled tag.

FGF2 蛋白作为一种多功能配体，与 FGFR1、FGFR2、FGFR3 和 FGFR4 结合，并且还充当对 FGF2 信号转导至关重要的整合素配体。与整合素 ITGAV:ITGB3 的相互作用对于该信号通路至关重要。FGF2 在调节细胞存活、细胞分裂、细胞分化和细胞迁移中发挥着关键作用。此外，它在体外可作为有效的有丝分裂原，并具有诱导血管生成的能力。FGF2 的影响延伸到通过 ERK1/2 磷酸化促进视网膜晶状体纤维分化。FGF2 以单体或同二聚体形式存在，与其受体 FGFR1、FGFR2、FGFR3 和 FGFR4 相互作用，并且硫酸乙酰肝素糖胺聚糖增强其与这些受体的亲和力。此外，FGF2 与其他蛋白质（如 CSPG4、FGFBP1、TEC 和 FGFBP3）形成复合物，有助于其多样化的细胞功能。与整合素 ITGAV:ITGB3 的相互作用对于 FGF2 信号传导是不可或缺的，与 SNORC 和磷脂酰肌醇蛋白聚糖 GPC3 的额外相互作用进一步说明了 FGF2 相关蛋白的复杂网络。

Bovine

E. coli

N-6*His

P03969 (P10-S155)

281161

PALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGPKTGPGQKAILFLPMSAKS

20.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.