FKBP12 蛋白, Human (His)

FKBP12 protein maintains TGFBR1 in an inactive state, inhibits activin signaling by recruiting SMAD7, and modulates RYR1 calcium channel activity. As a PPIase, it speeds up protein folding. FKBP12's multifunctionality underscores its regulatory role in cellular processes, emphasizing its importance in signaling and protein folding. FKBP12 Protein, Human (His) is the recombinant human-derived FKBP12 protein, expressed by E. coli , with C-His labeled tag.

FKBP12 蛋白在维持 TGFBR1（TGF-β 的丝氨酸/苏氨酸激酶受体）的非活性构象中发挥着至关重要的作用，可在没有配体的情况下有效防止受体激活。此外，FKBP12 将 SMAD7 招募到 ACVR1B，抑制 SMAD2 和 SMAD3 与激活素受体复合物的结合，从而阻断激活素信号传导。这种多功能蛋白还可以调节 RYR1 钙通道的活性。作为一种肽基脯氨酰顺反异构酶 (PPIase)，FKBP12 通过催化寡肽中脯氨酸酰亚胺肽键的异构化来加速蛋白质折叠。FKBP12 的多种功能凸显了其在各种细胞过程中的调节作用，强调了其在细胞内信号传导和蛋白质折叠中的重要性。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

C-His

P62942/NP_463460.1 (M1-E108)

2280  [NCBI]

Approximately 12.9 kDa.

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.22 μm filtered solution of PBS, 10% glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.