2. 重组蛋白
  3. CAR-T related Proteins Receptor Proteins
  4. Folate Receptor alpha (FR-alpha)
  5. FOLR1 蛋白, Cynomolgus/Rhesus Macaque (209a.a, HEK293, His)

FOLR1 蛋白, Cynomolgus/Rhesus Macaque (209a.a, HEK293, His)

目录号: HY-P77664
产品使用指南

FOLR1 是叶酸受体，与叶酸和还原性叶酸衍生物结合，促进 5-甲基四氢叶酸和叶酸类似物进入细胞内部。FOLR1 通过 EGFR/AKT/GSK3β 轴增强 β-catenin 的稳定性和核易位，从而促进喉鳞状细胞癌 (LSCC) 的增殖和迁移。FOLR1 在多种肿瘤中高表达是许多癌症的潜在预后和治疗靶点。FOLR1 蛋白, Cynomolgus/Rhesus Macaque (209a.a, HEK293, His) 是重组的 FOLR1 蛋白，由 HEK293 表达，带有 C-His 标签。

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描述

FOLR1 is a folic acid receptor that binds to folic acid and reductive folic acid derivatives and promotes the entry of 5-methyltetrahydrofolate and folate analogs into the cell interior. FOLR1 enhances the stability and nuclear translocation of β-catenin through the EGFR/AKT/GSK3β axis, thereby promoting the proliferation and migration of laryngeal squamous cell carcinoma (LSCC). FOLR1 is highly expressed in a variety of tumors and is a potential prognostic and therapeutic target for many cancers. FOLR1 Protein, Cynomolgus/Rhesus Macaque (209a.a, HEK293, His) is the recombinant cynomolgus, Rhesus Macaque-derived FOLR1 protein, expressed by HEK293 , with C-His labeled tag.
研究背景

FOLR1 是叶酸受体 (FOLR) 家族的成员，FOLR1 蛋白是叶酸摄取的关键介质，与叶酸和还原性叶酸衍生物结合，促进 5-甲基四氢叶酸和叶酸类似物进入细胞内部。FOLR1 对正常胚胎发育和正常细胞增殖也很重要。FRA 的自身抗体与神经发育疾病有关，特别是脑叶酸缺乏症，精神分裂症和自闭症谱系障碍。FOLR1 通过 EGFR/AKT/GSK3β 轴增强 β-catenin 的稳定性和核易位，从而促进喉鳞状细胞癌 (LSCC) 的增殖和迁移。FOLR1 在多种肿瘤中高表达是许多癌症的潜在预后和治疗靶点。
种属

Cynomolgus; Rhesus Macaque
表达系统

HEK293
标签

C-His
蛋白编号

A0A2K5U044/NP_001181576.1 (R25-M233)
基因 ID

102132305/718388  [NCBI]
蛋白结构
N-term
FOLR1 (R25-M233)
Accession # A0A2K5U044/NP_001181576.1
His
C-term
同用名
FOLR; FOLR1; FBP; Folbp1; KB cells FBP; MOv18
分子量

35-45 kDa
纯度

Greater than 95% as determined by Tris-Bis PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FOLR1 Protein, Cynomolgus/Rhesus Macaque (209a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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