G-CSFR/CD114 蛋白, Mouse (HEK293, His)

The G-CSFR/CD114 protein serves as a receptor for granulocyte colony-stimulating factor (CSF3) and plays a key role in granulocyte development and function. As a homodimer, it binds two CSF3 molecules and transduces signals. G-CSFR/CD114 Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Mouse (HEK293, His) is 601 a.a., with molecular weight of 90-110 kDa.

G-CSFR/CD114 蛋白充当粒细胞集落刺激因子 (CSF3) 的受体，并且还可能在细胞表面的某些粘附或识别事件中发挥作用。该受体以同二聚体形式存在，结合两个 CSF3 分子，促进与粒细胞发育和功能相关的信号转导。此外，G-CSFR/CD114 与 CEACAM1 相互作用，导致 CSF3R-STAT3 通路下调。该过程涉及招募 PTPN6，随后使 CSF3R 去磷酸化，揭示 G-CSFR/CD114 在调节与粒细胞集落刺激因子反应相关的信号通路中的调节作用。这些相互作用凸显了 G-CSFR/CD114 在与免疫反应和造血相关的细胞过程中复杂的调节作用。

Immobilized Mouse G-CSF R, His Tag at 0.2 μg/mL (100 μl/well) on the plate. Dose response curve for Human G-CSF, hFc Tag with the EC₅₀ of ≤3 ng/mL determined by ELISA.

Mouse

HEK293

C-His

P40223 (C26-D626)

12986  [NCBI]

90-110 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.