Gamma-hemolysin component A 蛋白, S. aureus (Myc, His)

Gamma-hemolysin component A (HLgA) functions as a toxin and creates cell membrane pores with hemolytic and leukotoxic activities. Its action depends on sequential binding and cooperative association with class S and class F components to form heterooligomeric complexes. Gamma-hemolysin component A Protein, S. aureus (Myc, His) is the recombinant Staphylococcus aureus-derived Gamma-hemolysin component A protein, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of Gamma-hemolysin component A Protein, S. aureus (Myc, His) is 280 a.a., with molecular weight of ~39.4 kDa.

γ-溶血素成分 A (HLgA) 是一种毒素，通过在细胞膜上产生孔来发挥作用，表现出溶血和白细胞毒性活性。其毒性作用取决于 S 类和 F 类成分的顺序结合和协同作用，从而导致异寡聚复合物的形成。在同时产生 γ-溶血素和杀白细胞素的菌株中，HlgA（S 类）与 HlgB（F 类）结合，从而构成 AB 毒素。此外，HLgA 还可以与 LukF-PV 形成复合物，展示了该毒素所采用的多功能相互作用和潜在的合作机制。

Staphylococcus aureus

E. coli

N-His;C-Myc

P0A073 (E30-K309)

59701246

ENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK

Approximately 39.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.