GDF-8 蛋白, Human/Mouse/Rat (HEK293)

GDF-8 (Growth Differentiation Factor 8) functions as a specific negative regulator of skeletal muscle growth. It forms homodimers linked by disulfide bonds and inhibits WFIKKN2 activity through interaction. GDF-8 also interacts with FST3, playing a regulatory role in skeletal muscle growth modulation. GDF-8 Protein, Human/Mouse/Rat (HEK293) is the recombinant rat-derived GDF-8 protein, expressed by HEK293 , with tag free. The total length of GDF-8 Protein, Human/Mouse/Rat (HEK293) is 114 a.a., with molecular weight of 12-15 kDa.

GDF-8（生长分化因子 8）是骨骼肌生长的特定负调节因子。它形成通过二硫键连接的同二聚体并与 WFIKKN2 相互作用，从而抑制后者的活性。此外，GDF-8 与 FSTL3 相互作用，有助于发挥其在调节骨骼肌生长中的调节作用。

Determined by its ability to inhibit the proliferation of MPC-11 cells. The ED₅₀ for this effect is 23.3 ng/mL.

Mouse; Human; Rat

HEK293

Tag Free

O14793 (K262-S375)

2660  [NCBI]

KRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS

12-15 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.