Gliomedin 蛋白, Human (HEK293, Fc, solution)

Gliomedin protein is a collagen-rich homotrimer that critically binds to NRCAM and NFASC and plays a key role in establishing and preserving nodes of Ranvier on myelinated axons. It mediates Schwann cell-axon interactions and promotes sodium channel clustering for efficient action potential propagation. Gliomedin Protein, Human (HEK293, Fc, solution) is the recombinant human-derived Gliomedin protein, expressed by HEK293 , with N-hFc labeled tag.

Gliomedin 是一种以胶原样结构域为特征的同源三聚蛋白，作为 NRCAM 和 NFASC/neurofascin 的重要配体，在沿有髓轴突的 Ranvier 节点的建立和保存中发挥着关键作用。其意义在于通过与 NRCAM 和 NFASC 结合来介导雪旺细胞微绒毛和轴突之间的相互作用。朗飞结是有髓轴突上的重要区域，其中包含对动作电位的跳跃传播至关重要的钠通道。格洛梅定通过促进半结点的融合，专门参与发育过程中节点的形成，并且它对于半结点处钠通道的正确聚集是必不可少的。此外，与 NRCAM 合作，Gliomedin 有助于维持 Ranvier 完全成熟节点上的 NFASC 和钠通道簇。此外，它与神经胶质 NRCAM 的相互作用增强了它与轴突 NFASC 的结合亲和力。格里奥梅定的复杂参与强调了其在 Ranvier 节点的结构完整性和功能组织中的重要性。

Human

HEK293

N-hFc

AAQ88511.1 (M1-Q427)

342035  [NCBI]

Predict MW: 74.3 kDa.

Greater than 85% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.