glycoprotein B/gB 蛋白, HHV-2 (Cell-Free, His)

Glycoprotein B (gB) is a key envelope glycoprotein that forms unique spikes on the surface of viral particles and plays a crucial role in the initial attachment of the heparan sulfate moiety of the host cell surface proteoglycan. This interaction is a fundamental step in the viral entry process. glycoprotein B/gB Protein, HHV-2 (Cell-Free, His) is the recombinant Virus-derived glycoprotein B/gB protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of glycoprotein B/gB Protein, HHV-2 (Cell-Free, His) is 882 a.a., with molecular weight of 99.7 kDa.

糖蛋白 B (gB) 是病毒颗粒结构中重要的包膜糖蛋白，在病毒包膜表面形成刺突。其主要作用在于最初附着于宿主细胞表面蛋白聚糖上存在的硫酸乙酰肝素部分。这种相互作用对于病毒进入宿主细胞的初始阶段至关重要。随后，gB 积极参与病毒和细胞膜的融合，促进病毒进入宿主细胞。最初与宿主受体结合后，融合过程由至少由 gB 和异二聚体 gH/gL 组成的融合机制协调。此外，gB 可能在病毒粒子排出过程中介导病毒粒子包膜与外核膜之间的融合中发挥作用。在结构上，gB 以同源三聚体形式存在，通过二硫键连接，它与硫酸乙酰肝素蛋白聚糖以及 gH/gL 异二聚体相互作用，突出了其在病毒进入和排出的复杂机制中的关键作用（参考：提供的信息）。

Virus

E. coli Cell-free

N-10*His

P08666 (A23-L904)

/

APAAPAAPRASGGVAATVAANGGPASRPPPVPSPATTKARKRKTKKPPKRPEATPPPDANATVAAGHATLRAHLREIKVENADAQFYVCPPPTGATVVQFEQPRRCPTRPEGQNYTEGIAVVFKENIAPYKFKATMYYKDVTVSQVWFGHRYSQFMGIFEDRAPVPFEEVIDKINTKGVCRSTAKYVRNNMETTAFHRDDHETDMELKPAKVATRTSRGWHTTDLKYNPSRVEAFHRYGTTVNCIVEEVDARSVYPYDEFVLATGDFVYMSPFYGYREGSHTEHTSYAADRFKQVDGFYARDLTTKARATSPTTRNLLTTPKFTVAWDWVPKRPAVCTMTKWQEVDEMLRAEYGGSFRFSSDAISTTFTTNLTEYSLSRVDLGDCIGRDAREAIDRMFARKYNATHIKVGQPQYYLATGGFLIAYQPLLSNTLAELYVREYMREQDRKPRNATPAPLREAPSANASVERIKTTSSIEFARLQFTYNHIQRHVNDMLGRIAVAWCELQNHELTLWNEARKLNPNAIASATVGRRVSARMLGDVMAVSTCVPVAPDNVIVQNSMRVSSRPGTCYSRPLVSFRYEDQGPLIEGQLGENNELRLTRDALEPCTVGHRRYFIFGGGYVYFEEYAYSHQLSRADVTTVSTFIDLNITMLEDHEFVPLEVYTRHEIKDSGLLDYTEVQRRNQLHDLRFADIDTVIRADANAAMFAGLCAFFEGMGDLGRAVGKVVMGVVGGVVSAVSGVSSFMSNPFGALAVGLLVLAGLVAAFFAFRYVLQLQRNPMKALYPLTTKELKTSDPGGVGGEGEEGAEGGGFDEAKLAEAREMIRYMALVSAMERTEHKARKKGTSALLSSKVTNMVLRKRNKARYSPLHNEDEAGDEDEL

99.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.