GM2A 蛋白, Human (HEK293, His)

Ganglioside GM2 activator (GM2A) is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. GM2A catalyzes the degradation of the ganglioside GM2 as well as affects lipid storage and neuromuscular process controlling balance. GM2A Protein, Human (HEK293, His) is the recombinant human-derived GM2A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM2A Protein, Human (HEK293, His) is 162 a.a., with molecular weight of 19-22 kDa.

神经节苷脂 GM2 激活剂 (GM2A) 是一种小的糖脂转运蛋白，是溶酶体酶 β-己糖胺酶 A 的底物特异性辅因子。GM2A 与 β-己糖胺酶 A 一起催化神经节苷脂 GM2 和其他含有末端 N-乙酰己糖胺的分子的降解。GM2A 突变可导致 GM2-神经节苷脂贮积症 AB 型或 Tay-Sachs 病的 AB 型。
GM2A 的大结合囊袋可容纳多种单链磷脂和脂肪酸，GM2A 还具有非钙依赖性磷脂酶活性和胆固醇转运活性，并影响脂质储存和控制平衡的神经肌肉过程^[1][2]。

Human

HEK293

C-6*His

AAH09273.1 (S32-I193)

2760  [NCBI]

SSFSWDNCDEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI

19-22 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.