GM2A 蛋白, Human (sf9, His)

GM2A Protein is a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2A, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. And it is a lipid transfer protein that stimulates the enzymatic processing of gangliosides, and also T-cell activation through lipid presentation. GM2A Protein, Human (sf9, His) is the recombinant human-derived GM2A protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of GM2A Protein, Human (sf9, His) is 170 a.a., with molecular weight of ~25 kDa.

神经节苷脂 GM2 激活剂 (GM2A) 是一种小型糖脂转运蛋白，可作为溶酶体酶 beta-己糖胺酶 A 的底物特异性辅因子。Beta-己糖胺酶 A 与 GM2A 一起催化神经节苷脂 GM2 和其他含有末端N-乙酰基己糖胺分子的降解。GM2A 含有多种单链磷脂和脂肪酸，是一种脂质转移蛋白，可刺激神经节苷脂的酶促加工，并通过脂质呈递激活 T 细胞。它从膜中提取单个 GM2 分子，并将其以可溶形式呈现给 beta-己糖胺酶 A，以裂解 N-乙酰基-D-半乳糖胺并转化为 GM3。此外，GM2A 具有胆固醇转移活性。GM2A基因的突变导致 AB 型 GM2 神经节苷脂病或 Tay-Sachs 病的 AB 变体^[1][2]。

Human

Sf9 insect cells

C-His

AAA35907.1 (H24-I193)

2760  [NCBI]

Approximately 25 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.