GMP IFN-gamma 蛋白, Human

IFN-gamma Protein is a dimeric soluble cytokine. It exerts antibacterial, antiviral and antitumor effects through JAK-STAT, mTOR, MAPK and PI3K/AKT signaling pathways. GMP IFN-gamma Protein, Human is the recombinant human-derived IFN-gamma protein, expressed by E. coli , with tag free. The total length of GMP IFN-gamma Protein, Human is 143 a.a., with molecular weight of ~16.7 kDa.

IFN-gamma 是一种二聚体可溶性细胞因子，是II 型干扰素中唯一的成员。IFN-gamma 由免疫细胞T 细胞和NK 细胞产生，通过激活效应免疫细胞和增强抗原呈递，在抗菌、抗病毒和抗肿瘤反应中发挥重要作用。IFN-gamma 通过JAK-STAT 通路与其受体IFNGR1 相互作用后影响基因调控，也可触发mTOR、MAPK 和PI3K/AKT信号通路。IFN-gamma 通过诱导催化蛋白酶体亚基替换为免疫蛋白酶体亚基，在I 类抗原递呈途径中发挥作用。IFN-gamma 通过促进组织蛋白酶B/CTSB、H/CTSH 和L/CTSL 等几个关键分子的表达，上调细胞表面的MHC II 复合物。IFN-gamma 通过影响造血干细胞的发育、静止和分化，参与造血干细胞在发育和稳态条件下的调控。

Measured in anti-viral assays using WISH cells infected with vesicular stomatitisvirus (VSV) and the ED₅₀ is 8-80 pg/mL.

Human

E. coli

Tag Free

P01579 (Q24-Q166)

3458  [NCBI]

Approximately 16.7 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<0.01 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.