1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Peptide Hormone & Neuropeptides
  4. Glycoprotein Hormone alpha-2 (GPHA2)
  5. GPHA2 蛋白, Human (HEK293, Fc)

GPHA2 蛋白, Human (HEK293, Fc)

目录号: HY-P76959
产品使用指南 技术支持

GPHA2 作为异二聚体糖蛋白激素与 GPHB5 一起形成复合物,结合并激活促甲状腺激素受体 (TSHR),从而触发 cAMP 产生升高。这种蛋白质复合物在甲状腺细胞代谢调节中发挥关键作用,控制甲状腺细胞的基本代谢过程。GPHA2 蛋白, Human (HEK293, Fc) 是重组的 GPHA2 蛋白,由 HEK293 表达,带有 C-mFc 标签。

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描述

GPHA2 acts as a heterodimeric glycoprotein hormone together with GPHB5 to form a complex that binds and activates the thyroid-stimulating hormone receptor (TSHR), thereby triggering elevated cAMP production. This protein complex plays a key role in the regulation of thyroid cell metabolism, controlling the basic metabolic processes of thyroid cells. GPHA2 Protein, Human (HEK293, Fc) is the recombinant human-derived GPHA2 protein, expressed by HEK293 , with C-mFc labeled tag.

研究背景

GPHA2(糖蛋白激素 Alpha 2)与 GPHB5 一起充当重要的异二聚体糖蛋白激素,能够结合并激活促甲状腺激素受体 (TSHR),最终导致 cAMP 产量增加。这种糖蛋白激素复合物在甲状腺细胞代谢的调节中起着核心作用,表明其在控制甲状腺功能和激素平衡中具有重要意义。GPHA2 和 GPHB5 之间的功能伙伴关系通过异二聚体的形成而凸显,并且该复合物与 TSHR 特异性相互作用,从而启动导致 cAMP 水平增加的级联反应。

种属

Human

表达系统

HEK293

标签

C-mFc

蛋白编号

Q96T91 (Q24-Y129)

基因 ID
蛋白结构
N-term
GPHA2 (Q24-Y129)
Accession # Q96T91
mFc
C-term
同用名
Glycoprotein hormone alpha-2; Putative secreted protein Zsig51; GPA2; ZSIG51
分子量

38-43 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
GPHA2 Protein, Human (HEK293, Fc)
目录号:
HY-P76959
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