GPHA2 蛋白, Human (HEK293, His)

GPHA2 acts as a heterodimeric glycoprotein hormone together with GPHB5 to form a complex that binds and activates the thyroid-stimulating hormone receptor (TSHR), thereby triggering elevated cAMP production. This protein complex plays a key role in the regulation of thyroid cell metabolism, controlling the basic metabolic processes of thyroid cells. GPHA2 Protein, Human (HEK293, His) is the recombinant human-derived GPHA2 protein, expressed by HEK293 , with C-His labeled tag. The total length of GPHA2 Protein, Human (HEK293, His) is 106 a.a., with molecular weight of ~23 kDa.

GPHA2（糖蛋白激素 Alpha 2）与 GPHB5 一起充当重要的异二聚体糖蛋白激素，能够结合并激活促甲状腺激素受体 (TSHR)，最终导致 cAMP 产量增加。这种糖蛋白激素复合物在甲状腺细胞代谢的调节中起着核心作用，表明其在控制甲状腺功能和激素平衡中具有重要意义。GPHA2 和 GPHB5 之间的功能伙伴关系通过异二聚体的形成而凸显，并且该复合物与 TSHR 特异性相互作用，从而启动导致 cAMP 水平增加的级联反应。

Human

HEK293

C-6*His

Q96T91 (Q24-Y129)

170589  [NCBI]

QEAVIPGCHLHPFNVTVRSDRQGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSVSQCCTISGLKKVKVQLQCVGSRREELEIFTARACQCDMCRLSRY

Approximately 23 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.