GPIHBP1 蛋白, Human (HEK293, Fc)

GPIHBP1 Protein mediates lipid metabolism by transporting lipoprotein lipase LPL, anchoring it in capillaries, and safeguarding against loss of activity. It crucially contributes to chylomicron lipolysis, triglyceride metabolism, and overall lipid homeostasis. The protein binds chylomicrons, APOA5-containing phospholipid particles, and HDL, highlighting its role in lipid interactions and uptake. With predominantly monomeric states and 1:1 stoichiometry in LPL interaction, GPIHBP1 precisely orchestrates lipid processing, emphasizing its significance in vascular lipid transport. GPIHBP1 Protein, Human (HEK293, Fc) is the recombinant human-derived GPIHBP1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of GPIHBP1 Protein, Human (HEK293, Fc) is 130 a.a., with molecular weight of 50-65 kDa.

GPIHBP1 蛋白通过促进脂蛋白脂肪酶 LPL 从毛细血管内皮细胞的基底外侧转运至顶面并将 LPL 锚定在毛细血管腔内的内皮细胞表面上，充当脂质代谢的关键介质。通过这种能力，GPIHBP1 可以保护 LPL 免遭活性丧失和 ANGPTL4 介导的解折叠，在 LPL 乳糜微粒的脂肪分解过程、甘油三酯代谢和整体脂质稳态中发挥关键作用。该蛋白具有结合乳糜微粒和含有 APOA5 的磷脂颗粒的能力，有助于其在脂蛋白相互作用中的作用。此外，GPIHBP1 与高密度脂蛋白 (HDL) 结合，表明在从 HDL 摄取脂质中发挥作用。该蛋白质主要表现出单体状态，但也可以形成同二聚体和同寡聚体。它与 LPL 的相互作用以 1:1 的化学计量发生，强调了它参与脂质加工的精确性。GPIHBP1 复杂的相互作用网络，包括与 HDL 和 APOA5 的相互作用网络，强调了其在血管系统内协调脂质运输和维持脂质稳态方面的重要性。

Human

HEK293

C-hFc

Q8IV16 (T22-G151)

338328  [NCBI]

TQQEEEEEDEDHGPDDYDEEDEDEVEEEETNRLPGGRSRVLLRCYTCKSLPRDERCNLTQNCSHGQTCTTLIAHGNTESGLLTTHSTWCTDSCQPITKTVEGTQVTMTCCQSSLCNVPPWQSSRVQDPTG

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.