GPT1 蛋白, Human (His)

The GPT1 protein is a key player that catalyzes the reversible cleavage of L-arginine succinate, which is critical in the urea cycle, aids in hepatic nitrogen detoxification and promotes de novo L-arginine synthesis. GPT1 regulates intracellular and extracellular L-arginine pools, which are critical for nitrogen homeostasis. GPT1 Protein, Human (His) is the recombinant human-derived GPT1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GPT1 Protein, Human (His) is 495 a.a., with molecular weight of 58.5 kDa.

精氨基琥珀酸裂解酶 (ASL) 蛋白通过催化 L-精氨基琥珀酸可逆裂解为富马酸和 L-精氨酸（尿素循环中的关键步骤）发挥着关键作用。该过程主要有助于肝脏氮解毒，导致尿素排泄，并促进非肝组织中 L-精氨酸的从头合成。ASL 是细胞内和细胞外 L-精氨酸库的重要调节剂，在维持氮稳态方面发挥着关键作用。作为瓜氨酸-一氧化氮循环的一部分，ASL 与精氨酸琥珀酸合酶 (ASS1)、转运蛋白 SLC7A1 和一氧化氮合酶（NOS1、NOS2 或 NOS3）形成组织特异性多蛋白复合物。该复合物允许细胞自主合成 L-精氨酸，同时参与细胞外 L-精氨酸至一氧化氮合成途径的通道，展示了 ASL 在氮代谢和细胞信号传导中的多方面调节功能。

Human

E. coli

N-6*His

P24298 (A2-S496)

2875

58.5kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.