1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. Granzyme B/GZMB 蛋白, Mouse (CHO)

Granzyme B/GZMB 蛋白, Mouse (CHO)

目录号: HY-P7185
COA 产品使用指南

Granzyme B/GZMB 蛋白, Mouse (CHO)在细胞凋亡中发挥重要作用,通过刺激细胞因子释放参与炎症诱导,并参与细胞外基质重构。

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10 μg ¥2100 询问价格 & 货期
50 μg ¥6200 询问价格 & 货期

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描述

Granzyme B/GZMB Protein, Mouse (CHO) plays essential roles in apoptosis and is involved in inducing inflammation by stimulating cytokine release and is also involved in extracellular matrix remodeling.

研究背景

颗粒酶 B 在哺乳动物细胞凋亡中发挥重要作用[1]。颗粒酶 B 是一种丝氨酸蛋白酶,最常见于细胞毒性淋巴细胞 (CTL)、自然杀伤细胞 (NK 细胞) 和细胞毒性 T 细胞的颗粒中。它由这些细胞与成孔蛋白穿孔素一起分泌,以介导靶细胞的凋亡。颗粒酶 B 已被证明可通过刺激细胞因子释放来诱发炎症,并且还参与细胞外基质重塑[2]

种属

Mouse

表达系统

CHO

标签

Tag Free

蛋白编号

P04187 (I21-S247)

基因 ID
蛋白结构
N-term
GZMB (I21-S247)
Accession # P04187
C-term
中文名
重组小鼠颗粒酶 B (CHO 细胞表达)
同用名
rMuGranzyme B; CTLA-1; CCP1; Fragmentin-2; Gzmb
氨基酸序列

IIGGHEVKPHSRPYMALLSIKDQQPEAICGGFLIREDFVLTAAHCEGSIINVTLGAHNIKEQEKTQQVIPMVKCIPHPDYNPKTFSNDIMLLKLKSKAKRTRAVRPLNLPRRNVNVKPGDVCYVAGWGRMAPMGKYSNTLQEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVCKKVAAGIVSYGYKDGSPPRAFTKVSSFLSWIKKTMKSS

分子量

Approximately 32 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<0.2 EU/μg, determined by LAL method.

文件资料
参考文献

Granzyme B/GZMB Protein, Mouse (CHO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Granzyme B/GZMB Protein, Mouse (CHO)
目录号:
HY-P7185
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