Haptoglobin 蛋白, Human (HEK293, His)

Haptoglobin captures and binds free plasma hemoglobin, preventing kidney damage and promoting hepatic recycling of heme iron. It acts as an antioxidant, exhibits antibacterial activity, and modulates various aspects of the acute phase response. Haptoglobin Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived Haptoglobin protein, expressed by HEK293 , with C-6*His labeled tag. Haptoglobin Protein, Human (HEK293, His), has molecular weight of 16 & 40-75 kDa, respectively.

触珠蛋白的功能是捕获和结合游离血浆血红蛋白，防止肾脏损伤并促进血红素铁的肝脏回收。溶血期间，血红蛋白可积聚在肾脏中并分泌到尿液中。此外，触珠蛋白还充当抗氧化剂，具有抗菌活性，并在调节急性期反应的各个方面发挥作用。血红蛋白和触珠蛋白之间形成的复合物通过内吞溶酶体降解途径被肝 Kupfer 细胞上的巨噬细胞 CD163 清道夫受体有效清除。值得注意的是，α-2 等位基因 (2-2) 的未切割形式（称为连蛋白）通过调节细胞间紧密连接分解并影响对非自身抗原的耐受性和免疫性之间的平衡，对肠道通透性产生影响。

Human

HEK293

C-6*His

P00738-1 (V19-Q160&I162-N406)

3240  [NCBI]

VDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQ&ILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN

16&40-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.