HBP1 蛋白, Human (His)

HBP1 is a transcriptional repressor that regulates target genes by binding specifically to promoter regions, specifically favoring the sequence 5'-TTCATTCATTCA-3'.Its key role in the cell cycle and Wnt pathway involves promoting enhanced binding to the histone H1.0 promoter through the RB1 interaction.HBP1 Protein, Human (His) is the recombinant human-derived HBP1 protein, expressed by E.coli , with N-His labeled tag.

HBP1 是一种转录抑制因子，通过特异性结合靶基因的启动子区域来发挥其调节作用。它在控制细胞周期和 Wnt 通路中发挥着关键作用，显示出对序列 5'-TTCATTCATTCA-3' 的偏好。与 RB1 的相互作用增强了其与组蛋白 H1.0 启动子的结合，有助于其调节功能。此外，HBP1 破坏 DNA-TCF4 相互作用并与 SIN3A 的第二个 PAH 重复序列结合。值得注意的是，它与 TCF4 和 RB1 直接相互作用，进一步强调了它参与复杂的监管网络。

Human

E. coli

N-His

O60381 (P208-F345)

26959  [NCBI]

PSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINF

Approximately 17 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.