2. 重组蛋白
  3. Enzymes & Regulators
  4. Lyases (EC 4)
  5. GUCY2C/Guanylyl cyclase C 蛋白, Rat (HEK293, Myc, His)

GUCY2C/Guanylyl cyclase C 蛋白, Rat (HEK293, Myc, His)

目录号: HY-P71666
产品使用指南

GUCY2C 是一种鸟苷酸环化酶，对 GTP 合成 cGMP 具有至关重要的催化作用。作为大肠杆菌热稳定肠毒素的受体，GUCY2C 显着刺激哺乳动物细胞中的 cGMP 积累，强调其在介导对特定外部刺激的反应中的作用，并展示细胞信号传导中复杂的调节机制。GUCY2C/Guanylyl cyclase C 蛋白, Rat (HEK293, Myc, His) 是重组的 GUCY2C/鸟苷酸环化酶 C 蛋白，由 HEK293 表达，带有 N-His, C-Myc 标签。

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规格 是否有货
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描述

GUCY2C, a guanylyl cyclase, crucially catalyzes cGMP synthesis from GTP.As a receptor for E.coli heat-stable enterotoxin, GUCY2C significantly stimulates cGMP accumulation in mammalian cells, emphasizing its role in mediating responses to specific external stimuli and showcasing intricate regulatory mechanisms in cellular signaling.GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) is the recombinant rat-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with N-His, C-Myc labeled tag.
研究背景

GUCY2C 是一种鸟苷酸环化酶，在催化 GTP 合成环鸟苷酸 (cGMP) 方面发挥着关键作用。作为大肠杆菌热稳定肠毒素的受体，GUCY2C 通过显着刺激表达该蛋白的 cin 哺乳动物细胞的积累来对该毒素做出反应。这种相互作用凸显了细胞信号传导中复杂的调节机制，并强调了 GUCY2C 在介导对特定外部刺激的反应中的作用。
种属

Rat
表达系统

HEK293
标签

N-His;C-Myc
蛋白编号

P23897 (S23-Q429)
基因 ID
蛋白结构
N-term
10*His
GUCY2C/Guanylyl cyclase C (S23-Q429)
Accession # P23897
Myc
C-term
同用名
Gucy2c; Guc2c; Heat-stable enterotoxin receptor; STA receptor; EC 4.6.1.2; Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase
氨基酸序列

SQVRQKCHNGTYEISVLMMDNSAYKEPLQNLRDAVEEGLDIVRKRLREAELNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDRKMGCVLMGPSCTYSTFQMYLDTELNYPMISAGSFGLSCDYKETLTRILPPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLLFGHMLQTFLENGESVTTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPGLGPQ

分子量

Approximately 51.4 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GUCY2C/Guanylyl cyclase C Protein, Rat (HEK293, Myc, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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