Hepcidin/HAMP 蛋白, Human (GST)

The hepcidin/HAMP protein is a liver-produced hormone that is a major circulating regulator of iron absorption and distribution. It promotes endocytosis and degradation of ferroportin/SLC40A1, retaining iron within cells and reducing plasma iron flux. Hepcidin/HAMP Protein, Human (GST) is the recombinant human-derived Hepcidin/HAMP protein, expressed by E. coli , with N-GST labeled tag. The total length of Hepcidin/HAMP Protein, Human (GST) is 25 a.a., with molecular weight of 28-30 kDa.

铁调素是一种肝脏产生的激素，是铁吸收和全身分布的主要循环调节剂。其调节机制涉及促进铁转运蛋白/SLC40A1 的内吞作用和降解，导致铁保留在铁输出细胞内，并减少进入血浆的铁流量。铁调素控制进入血液的重要铁流量，包括肠道中膳食铁的吸收、巨噬细胞通过吞噬老化红细胞和其他细胞来回收铁，以及从肝细胞中动员储存的铁。此外，铁调素对多种细菌（包括大肠杆菌 ML35P、灰葡萄球菌、表皮葡萄球菌、金黄色葡萄球菌和 B 族链球菌）表现出强大的抗菌活性，对真菌白色念珠菌也有中等活性，但没有效果。对抗铜绿假单胞菌。

Human

E. coli

N-GST

P81172 (D60-T84)

57817  [NCBI]

DTHFPICIFCCGCCHRSKCGMCCKT

28-30 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.