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  4. HGFR 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)

HGFR 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)

目录号: HY-P72936
产品使用指南

HGFR 蛋白是一种受体酪氨酸激酶,通过结合肝细胞生长因子/HGF 配体来转导信号。它调节增殖、散射、形态发生和细胞存活。配体结合后,HGFR 会发生自磷酸化,为 PI3K、PLCG1、SRC、GRB2、STAT3 或 GAB1 等下游分子创建对接位点,激活 RAS-ERK、PI3K-AKT 和 PLCgamma-PKC 级联。HGFR 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc) 是重组的 HGFR 蛋白,由 HEK293 表达,带有 C-hFc 标签。

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描述

HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.

研究背景

肝细胞生长因子受体 (HGFR) 是一种受体酪氨酸激酶,通过与肝细胞生长因子/HGF 配体结合,充当细胞外基质的信号转导器。它在调节多种生理过程中发挥着关键作用,包括增殖、散射、形态发生和细胞存活。配体在细胞表面结合后,HGFR 在其胞内结构域上发生自磷酸化,为下游信号分子创建对接位点。被配体激活后,它与 PI3 激酶亚基 PIK3R1、PLCG1、SRC、GRB2、STAT3 或适配器 GAB1 相互作用,导致多个信号级联的激活,包括 RAS-ERK、PI3 激酶-AKT 和 PLCgamma-PKC。RAS-ERK 激活与形态发生效应相关,而 PI3K/AKT 协调促生存效应。在胚胎发育中,HGFR 信号传导有助于原肠胚形成、神经元前体的发育和迁移、血管生成和肾脏形成。在骨骼肌发育过程中,它对于肌肉祖细胞的迁移和次级成肌细胞的增殖至关重要。在成人中,它参与伤口愈合、器官再生、组织重塑,并促进造血细胞的分化和增殖。此外,在微生物感染的情况下,HGFR 作为 InlB 内单核细胞增生李斯特菌的受体,介导病原体进入细胞[1][2][3]

种属

Rhesus Macaque; Cynomolgus

表达系统

HEK293

标签

C-hFc

蛋白编号

NP_001162100.1 (E25-T932)

基因 ID
蛋白结构
N-term
HGFR (E25-T932)
Accession # NP_001162100.1
hFc
C-term
同用名
Hepatocyte growth factor receptor; HGF receptor; SF receptor; MET
氨基酸序列

MKAPAVLVPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETAIQNVILHEH HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPNQCPDCVVSAL GAKVLSSVKDRFINFFVGNTINSSYFPHHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE FRDSYPIKYIHAFESNNFIYFLTVQRETLNAQTFHTRIIRFCSLNSGLHSYMEMPLECIL TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRAEF TTALQRVDLFMGQFSEVLLTSISTFVKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL LDSHPVSPEVIVEHPLNQNGYTLVVTGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECPSGTWTQQICLPAIYKVFPTSAPLEGGTRLTICGWDFGFRRNNKFDLKK TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPIIT SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLHSVSVPRMVINVH EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL LKLNSELNIEWKQAISSTVLGKVIVQPDQNFT

分子量

Approximately 100.2&42.5 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293, Fc)
目录号:
HY-P72936
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