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  4. HSPBP1 蛋白, Human

HSPBP1 蛋白, Human

目录号: HY-P701386
COA 产品使用指南

HSPBP1 蛋白通过诱导 ATP 结合域的构象变化并破坏 ATP 结合来调节 HSPA1A 伴侣活性。这种干扰抑制 STUB1 介导的泛素化过程并阻止分子伴侣辅助的未成熟 CFTR 的降解。HSPBP1 蛋白, Human 是重组的 HSPBP1 蛋白，由 E. coli 表达，不带标签。HSPBP1 蛋白, Human 全长 276 个氨基酸。

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规格 价格 是否有货 数量
10 μg ￥1350 In-stock
50 μg ￥3750 询价
100 μg   询价  

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描述

HSPBP1 protein regulates HSPA1A chaperone activity by inducing conformational changes in the ATP-binding domain and disrupting ATP binding. This interference inhibits the STUB1-mediated ubiquitination process and blocks chaperone-assisted degradation of immature CFTR. HSPBP1 Protein, Human is the recombinant human-derived HSPBP1 protein, expressed by E. coli , with tag free. The total length of HSPBP1 Protein, Human is 276 a.a., .
研究背景

HSPBP1 蛋白通过诱导 HSPA1A ATP 结合域的构象变化，从而破坏 ATP 结合，对 HSPA1A 伴侣活性进行调节控制。这种干扰会抑制 STUB1 介导的泛素化过程，并阻碍分子伴侣辅助的未成熟 CFTR 降解。已知该蛋白与 HSPA1A 的 ATP 结合域相互作用，与 STUB1 和 HSPBP1 形成三元复合物。此外，它与 PGLYRP1 的相互作用可阻断 PGLYRP1-HSPA1A 复合物的细胞毒性活性，突出了 HSPBP1 在细胞过程中的多方面调节作用。
种属

Human
表达系统

E. coli
标签

Tag Free
蛋白编号

Q9NZL4 (R84-R359)
基因 ID

23640
蛋白结构
N-term
HSPBP1 (R84-R359)
Accession # Q9NZL4
C-term
同用名
HSPBP1; Hsp70-binding protein 1; HspBP1; Heat shock protein-binding protein 1; Hsp70-binding protein 2; HspBP2; Hsp70-interacting protein 1; Hsp70-interacting protein 2
分子量

30.9 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
性状

溶液.
组分

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH7.5, 200 mM NaCl, 20% glycerol.
内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

Please use rapid thawing with running water to thaw the protein.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
运输条件

Shipping with dry ice.
文件资料

COA (147 KB)

产品使用指南 (1213 KB)

HSPBP1 Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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目录号：
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