IDO-2 蛋白, Human (P.pastoris, His)

The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (P.pastoris, His) is the recombinant human-derived IDO-2 protein, expressed by P. pastoris , with N-His labeled tag. The total length of IDO-2 Protein, Human (P.pastoris, His) is 407 a.a., with molecular weight of ~50.4 kDa.

吲哚胺 2,3-双加氧酶 2 (IDO-2) 是一种酶，可催化犬尿氨酸途径中必需氨基酸色氨酸分解代谢的第一步和限速步骤。该途径对于色氨酸代谢的调节至关重要，并且对免疫调节具有影响。IDO-2 的活性通过限制色氨酸的可用性来促进免疫调节，进而影响免疫细胞功能。虽然 IDO-2 参与免疫调节，但正如某些研究表明的那样，它可能不会在色氨酸相关的肿瘤耐药性中发挥重要作用。

Human

P. pastoris

N-His

Q6ZQW0-1 (M1-G407)

169355  [NCBI]

MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG

Approximately 50.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.