IGFBP-1 蛋白, Human (HEK293, His)

IGFBP-1 protein extends the half-life of IGFs and modulates their activity. It can inhibit or stimulate IGFs' growth-promoting effects, altering their interaction with receptors and fine-tuning signaling pathways. IGFBP-1 promotes cell migration and binds to both IGF1 and IGF2, highlighting its versatile role in modulating IGF signaling pathways. IGFBP-1 Protein, Human (HEK293, His) is the recombinant human-derived IGFBP-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGFBP-1 Protein, Human (HEK293, His) is 234 a.a., with molecular weight of 30-35 kDa.

IGFBP-1 蛋白通过延长胰岛素样生长因子 (IGF) 的半衰期，在调节其活性方面发挥着至关重要的作用。IGFBP-1 在细胞培养中具有双重调节影响，可以抑制或刺激 IGF 的生长促进作用，凸显其对细胞过程的多功能影响。此外，IGFBP-1 参与改变 IGF 与其细胞表面受体之间的相互作用，有助于微调与 IGF 介导的细胞反应相关的信号通路。值得注意的是，IGFBP-1 促进细胞迁移，强调其更广泛地参与细胞动力学。重要的是，它对 IGF1 和 IGF2 的结合表现出相同的亲和力，表明它能够与多种 IGF 同工型相互作用，并强调 IGFBP-1 在调节 IGF 信号通路中作用的复杂性。

Human

HEK293

C-6*His

P08833 (A26-N259)

3484  [NCBI]

APWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN

30-35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.