IGFBP-2 蛋白, Rhesus Macaque (HEK293, His)

IGFBP‐2 is a member of a family of six insulin‐like growth factor (IGF) binding proteins. IGFBP-2 is the second most abundant IGFBP in the circulation and binds IGF-II with higher affinity than IGF-I. IGFBP-2 has been implicated in the regulation of IGF activity in most tissues and organs. IGFBP-2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived IGFBP-2 protein, expressed by HEK293 , with C-His labeled tag.

IGFBP‐2 是胰岛素样生长因子 (IGF) 结合蛋白家族的成员。IGFBP-2 是循环中第二丰富的 IGFBP，与 IGF-II 的结合比 IGF-I 具有更高的亲和力。IGFBP-2 与大多数组织和器官中IGF 活性的调节有关。IGFBP‐2 参与胰岛素样生长因子受体信号通路的调节^[1][2][3][4]。

Measured by its ability to inhibit the biological activity of IGF-I on MCF-7 human breast cancer cells. The ED₅₀ for this effect is 0.03282 µg/mL in the presence of 14 ng/mL rh IGF-I, corresponding to a specific activity is 3.047×10⁴ units/mg.

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  Measured by its ability to inhibit the biological activity of IGF-I on MCF-7 human breast cancer cells. The ED₅₀ for this effect is 0.03282 µg/mL in the presence of 14 ng/mL rh IGF-I, corresponding to a specific activity is 3.047×10⁴ units/mg.

Rhesus Macaque

HEK293

C-6*His

XP_001087071.1 (E38-Q326)

696214  [NCBI]

EVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVAEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEAHGVHTQRMQ

Approximately 33 kDa.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.