IL-11 蛋白, Human (CHO)

IL-11 Protein, Human (CHO) is a CHO cell derived protective factor, which has a protective role and can accelerate recovery of platelets, and remarkably lessen the extent of inflammatory responses.

重组人白细胞介素 11 (IL-11) 在炎症中发挥着非常重要的作用。作为一种重要的细胞因子，IL-11 会促进慢性胃炎症，并与 STAT3 和 STAT1 介导的肿瘤发生相关。此外，IL-11也是IL-13诱导的Th2介导的炎症性疾病和组织重塑中不可或缺的因子。IL-11具有多种生物学功能。它具有针对中子辐射损伤的保护作用，能够促进小肠损伤更快地恢复，并且还可以在感染的动物模型中响应炎症。研究表明，IL-11 可以保护脓毒症动物模型免受肝损伤。尽管 IL-11 在新生儿血小板生成中的作用尚不清楚，但据报道，IL-11 参与了早产儿脓毒症或坏死性小肠结肠炎 (NEC) 的内源性细胞因子反应。IL-11 还参与 NF-κB 信号通路，抑制 IL-6 可以减少结肠炎相关的肿瘤发生^[1]。重组人白细胞介素 11 在体外直接促进巨核细胞生成^[2]。

The ED₅₀ is <5 ng/mL as measured in a proliferation assay by T11 cells.

Human

CHO

Tag Free

P20809-1 (P22-L199)

3589  [NCBI]

PGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL

Approximately 23 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against PBS.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Wan B, et al. Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study. Cytokine. 2015 Dec;76(2):138-143.  [Content Brief]

  [2]. Weich NS, et al. Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro. Blood. 1997 Nov 15;90(10):3893-902.  [Content Brief]