IL-17A/F Heterodimer 蛋白, Rhesus Macaque (HEK293, His)

IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F^[1][2][3][4].IL-17A/F Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant rhesus macaque IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells.

IL-17A-17F 异二聚体蛋白是细胞因子 IL-17A 和 IL-17F 的异二聚体。IL-17A和IL-17F均属于IL-17细胞因子家族。IL-17A-17F 异二聚体、IL-17A 和 IL-17F 同二聚体可由分化的 Th17 细胞^[1][2]产生。IL-17F 与 IL-17A 最为相似（50% 同源性）^[2]。IL-17A 和 IL-17F 均可诱导抗菌肽、细胞因子（IL-6 和 GM-CSF）、趋化因子（CCL2、CCL7 和 CXCL1）和基质金属蛋白酶（MMP-1 和 MMP13）^{[2]< /sup>[3]}。IL-17A、IL-17F和IL-17A-17F使用相同的受体复合物：IL-17RA和IL-17RC异二聚体。它们触发性质相似的信号通路。IL-17A-17F 的生物活性介于 IL-17A（最强）和 IL-17F（最弱）之间^[2][4]。

Rhesus Macaque

HEK293

C-His

XP_001106391 (G24-A155)&NP_001248216 (R31-Q163)

708123  [NCBI]&708220  [NCBI]

Approximately 32.5 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Chen K, et al. Interluekin-17A (IL17A). Gene. 2017 May 30;614:8-14.  [Content Brief]

  [2]. Chang SH, et al. IL-17F: regulation, signaling and function in inflammation. Cytokine. 2009 Apr;46(1):7-11.  [Content Brief]

  [3]. Iwakura Y, et al. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev. 2008 Dec;226:57-79.  [Content Brief]

  [4]. McGeachy MJ, et al. The IL-17 Family of Cytokines in Health and Disease. Immunity. 2019 Apr 16;50(4):892-906.  [Content Brief]