IL-1F10/IL-38 蛋白, Mouse (His-SUMO, solution)

IL-1F10/IL-38 proteins regulate immune responses. IL-1F10/IL-38 Protein, Mouse (His-SUMO, solution) is the recombinant mouse-derived IL-1F10/IL-38 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of IL-1F10/IL-38 Protein, Mouse (His-SUMO, solution) is 152 a.a., with molecular weight of ~33 kDa.

IL-1F10/IL-38 蛋白具有免疫调节活性，通过影响细胞因子的产生发挥作用。虽然它不能独立诱导细胞因子的产生，但它在免疫反应中发挥调节作用。值得注意的是，IL-1F10/IL-38 减少了 T 细胞响应热灭活白色念珠菌产生的 IL22 和 IL17A，表明其调节特定免疫途径的能力。此外，它还能减少 IL36G 诱导的外周血单核细胞产生 IL8，突显其对细胞因子反应的更广泛影响。相反，IL-1F10/IL-38 会增加细菌脂多糖 (LPS) 刺激的树突状细胞产生 IL6，表明其参与多种免疫过程。作为 IL-36R/IL1RL2 的配体，IL-1F10/IL-38 参与复杂的相互作用，其与货物受体 TMED10 的结合促进从细胞质易位到内质网-高尔基体中间室 (ERGIC)，从而导致随后的分泌。

Measured by its ability to inhibit IL-6 secretion by THP-1 human acute monocytic leukemia cells. The ED₅₀ for this effect is 40.04 ng/mL, corresponding to a specific activity is 2.50×10⁴ U/mg.

• 
  Measured by its ability to inhibit IL-6 secretion by THP-1 human acute monocytic leukemia cells. The ED₅₀ for this effect is 40.04 ng/mL, corresponding to a specific activity is 2.50×10⁴ U/mg.

Mouse

E. coli

N-6*His;N-SUMO

Q8R459 (M1-R152)

215274

MCSLPMARYYIIKDAHQKALYTRNGQLLLGDPDSDNYSPEKVCILPNRGLDRSKVPIFLGMQGGSCCLACVKTREGPLLQLEDVNIEDLYKGGEQTTRFTFFQRSLGSAFRLEAAACPGWFLCGPAEPQQPVQLTKESEPSTHTEFYFEMSR

Approximately 33 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4, 50% Glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.