IL-1F10/IL-38 蛋白, Mouse (His-SUMO)

IL-1F10/IL-38 proteins regulate immune responses. IL-1F10/IL-38 Protein, Mouse (His-SUMO) is the recombinant mouse-derived IL-1F10/IL-38 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of IL-1F10/IL-38 Protein, Mouse (His-SUMO) is 152 a.a., with molecular weight of ~35 kDa.

IL-1F10/IL-38 蛋白具有免疫调节活性，通过影响细胞因子的产生发挥作用。虽然它不能独立诱导细胞因子的产生，但它在免疫反应中发挥调节作用。值得注意的是，IL-1F10/IL-38 减少了 T 细胞响应热灭活白色念珠菌产生的 IL22 和 IL17A，表明其调节特定免疫途径的能力。此外，它还能减少 IL36G 诱导的外周血单核细胞产生 IL8，突显其对细胞因子反应的更广泛影响。相反，IL-1F10/IL-38 会增加细菌脂多糖 (LPS) 刺激的树突状细胞产生 IL6，表明其参与多种免疫过程。作为 IL-36R/IL1RL2 的配体，IL-1F10/IL-38 参与复杂的相互作用，其与货物受体 TMED10 的结合促进从细胞质易位到内质网-高尔基体中间室 (ERGIC)，从而导致随后的分泌。

Mouse

E. coli

N-SUMO;N-6*His

Q8R459 (M1-R152)

215274  [NCBI]

MCSLPMARYYIIKDAHQKALYTRNGQLLLGDPDSDNYSPEKVCILPNRGLDRSKVPIFLGMQGGSCCLACVKTREGPLLQLEDVNIEDLYKGGEQTTRFTFFQRSLGSAFRLEAAACPGWFLCGPAEPQQPVQLTKESEPSTHTEFYFEMSR

Approximately 35 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in 20 mM Tris-HC1, 0.5 M NaCl, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.