IL-23 alpha & IL-12 beta Heterodimer 蛋白, Rabbit (HEK293, His)

The IL-23 alpha protein, part of the IL-6 superfamily, comprises IL-23 alpha and IL-12 beta subunits forming a biologically active complex. It crucially influences the differentiation and activation of Th17 cells, associated with autoimmune diseases. The heterodimer stimulates pro-inflammatory cytokines like IL-17 and IL-22, promoting inflammation and immune cell recruitment. Dysregulation is linked to autoimmune diseases, making IL-23 alpha a potential therapeutic target for immune response modulation and inflammation control. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His) is a recombinant protein dimer complex containing Rabbit-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293, with C-His labeled tag. IL-23 alpha & IL-12 beta Heterodimer Protein, Rabbit (HEK293, His), has molecular weight of ~43 kDa & 23 kDa, respectively.

IL-23 α蛋白属于IL-6超家族，是一组在免疫调节和炎症中具有多种功能的细胞因子。这种异二聚体蛋白由两个亚基 IL-23 α 和 IL-12 β 组成，它们结合形成生物活性复合物。IL-23 α 在 T 辅助细胞 17 (Th17) 细胞的分化和激活中发挥着至关重要的作用，Th17 细胞是 CD4+ T 细胞的一个子集，参与自身免疫性疾病和慢性炎症的发病机制。它刺激促炎细胞因子（例如 IL-17 和 IL-22）的产生，并促进组织炎症和免疫细胞募集。IL-23α的失调与多种自身免疫性疾病有关，使其成为旨在调节免疫反应和控制炎症的治疗干预的有吸引力的目标。

Immobilized Human IL-23 R at 10 μg/mL (100 μL/well) can bind Rabbit IL-23 alpha & IL-12 beta Heterodimer Protein, The ED₅₀ for this effect is 0.1880 μg/mL.

• 
  Immobilized Human IL-23 R at 10 μg/mL (100 μL/well) can bind Rabbit IL-23 alpha & IL-12 beta Heterodimer Protein, The ED₅₀ for this effect is 0.1880 μg/mL.

Rabbit

HEK293

C-His

G1SSM0 (V22-P191)&G1TBD7 (I23-N324)

100352065  [NCBI]&100354852  [NCBI]

Approximately 43 kDa & 23 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.