ILDR2 蛋白, Human (HEK293, His)

ILDR2 proteins play multiple roles in cellular processes, participating in ER stress pathways, affecting lipid homeostasis, and affecting insulin secretion. It is involved in maintaining epithelial barrier function and recruiting MARVELD2/trifibrin into tight junctions, emphasizing its role in cellular integrity. ILDR2 Protein, Human (HEK293, His) is the recombinant human-derived ILDR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ILDR2 Protein, Human (HEK293, His) is 166 a.a., with molecular weight of 45-55 kDa.

ILDR2 蛋白似乎是一个多功能参与者，在细胞过程中发挥多种作用。它可能参与内质网应激途径，对脂质稳态和胰岛素分泌产生影响，从而暗示其在代谢调节中的潜在意义。与 ILDR1 和 LSR 一起，ILDR2 通过将 MARVELD2/tricellulin 招募到三细胞紧密连接来维持上皮屏障功能，强调其在细胞完整性中的作用。此外，作为在免疫细胞和炎症组织上表达的 B7 样蛋白家族的成员，ILDR2 表现出 T 细胞抑制活性，表明具有免疫调节功能。在内耳中，它可能通过与 TRA2A、TRA2B 和 SRSF1 相互作用来调节选择性前 mRNA 剪接。该蛋白质复杂的相互作用网络，包括 MARVELD2、OCLN、P4HB 和 HSPA5，进一步强调了其多方面的性质。值得注意的是，与 HSPA5 的相互作用稳定了 ILDR2 的表达，有助于其细胞调节。了解控制 ILDR2 多种功能的具体机制可以为其在代谢过程、细胞完整性、免疫调节和前 mRNA 剪接调节中的作用提供有价值的见解。

Human

HEK293

C-6*His

Q71H61 (L21-E186)

387597  [NCBI]

LQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPE

45-55 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.