INHBE 蛋白, Human (HEK293, Fc)

The INHBE protein is an important molecular switch that coordinates the inhibin and activin systems to regulate pituitary follicle-stimulating hormone secretion. Its critical role extends to multiple physiological functions, including hormone secretion, cell development, insulin release, and bone growth. INHBE Protein, Human (HEK293, Fc) is the recombinant human-derived INHBE protein, expressed by HEK293 , with N-hFc labeled tag. The total length of INHBE Protein, Human (HEK293, Fc) is 114 a.a., with molecular weight of ~40.9 kDa.

INHBE 蛋白在抑制素和激活素系统的复杂协调中发挥着关键作用，作为抑制或激活垂体促卵泡素分泌的分子开关。在更广泛的背景下，抑制素和激活素，以及扩展的 INHBE，有助于调节多种生理功能，包括下丘脑和垂体激素分泌、性腺激素分泌、生殖细胞发育和成熟、红细胞分化、胰岛素分泌、神经细胞存活、胚胎轴向发育和骨骼生长。抑制素和激活素之间的动态相互作用通过其相反的功能得到强调，其中以异二聚体结构（如抑制素 A 和抑制素 B）为代表的抑制素会抵消激活素的作用。在结构上，INHBE 通过与 α 和 β 亚基结合以同二聚体或异二聚体构型存在，并通过一个或多个二硫键错综复杂地连接。值得注意的是，抑制素以包含一个 α 和一个 β 亚基的异二聚体形式存在，而激活素，无论是同二聚体还是异二聚体形式，都完全由 β 亚基组成，这说明了 INHBE 在形成不同的生理反应中所发挥的微妙而多样的调节作用。

Human

HEK293

N-hFc

P58166 (T237-S350)

83729  [NCBI]

TPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS

Approximately 40.9 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 (Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.) or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.