Insulin 蛋白, Human (P.pastoris)

Insulin is an important hormone in glucose regulation, reducing blood glucose concentrations by increasing cellular permeability to simple sugars, amino acids, and fatty acids. Its multiple effects include accelerating glycolysis, promoting pentose phosphate cycle, and promoting hepatic glycogen synthesis. Insulin Protein, Human (P.pastoris) is a recombinant protein dimer complex containing human-derived Insulin protein, expressed by P. pastoris , with tag free. Insulin Protein, Human (P.pastoris), has molecular weight of ~6 kDa.

胰岛素是葡萄糖调节的关键激素，通过增强细胞对单糖、氨基酸和脂肪酸的通透性，有效降低血糖浓度。其多方面作用包括加速糖酵解、促进磷酸戊糖循环以及促进肝脏中糖原的合成。胰岛素分子本身由两个亚基组成，即 B 链和 A 链，通过两个二硫键错综复杂地连接。正如最近的研究所记录的，这些结构特征支撑了激素在协调对维持葡萄糖稳态至关重要的代谢过程中的重要作用。

Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells and the ED₅₀ is typically 0.2-1 µg/mL.

Human

P. pastoris

Tag Free

P01308-1 (F25-K53&G90-N110)

3630  [NCBI]

Approximately 6 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.