Integrin alpha L beta 2 蛋白, Mouse (HEK293, His)

Integrin alpha L beta 2 Protein, a receptor for ICAM1, ICAM2, ICAM3, ICAM4, and F11R, participates in immune phenomena, including leukocyte-endothelial cell interaction, cytotoxic T-cell killing, and antibody-dependent killing. It contributes to natural killer cell cytotoxicity and leukocyte adhesion and transmigration. Essential for common lymphoid progenitor cell generation, indicating a role in lymphopoiesis. In association with ICAM3, it contributes to apoptotic neutrophil phagocytosis by macrophages. Interacts with THBD. Integrin alpha L beta 2 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived Integrin alpha L beta 2 protein, expressed by HEK293, with C-His labeled tag. Integrin alpha L beta 2 Protein, Mouse (HEK293, His), has molecular weight of 160-180 kDa (ITGAL) & 90-105 kDa (ITGB2), respectively.

整合素 α L β 2 (ITGAL/ITGB2) 作为 ICAM1、ICAM2、ICAM3 和 ICAM4 的受体，还通过其 ITGAL 亚基与泛素样蛋白 ISG15 的分泌形式相互作用。此外，它作为 F11R 受体发挥作用，并在免疫过程中发挥作用，例如白细胞-内皮细胞相互作用、细胞毒性 T 细胞介导的杀伤以及粒细胞和单核细胞的抗体依赖性杀伤。ITGAL/ITGB2 有助于自然杀伤细胞的细胞毒性以及白细胞粘附和迁移，涉及 T 细胞和中性粒细胞。其重要性延伸到骨髓中共同淋巴祖细胞的产生，表明在淋巴细胞生成中的作用。此外，与 ICAM3 相关，ITGAL/ITGB2 有助于巨噬细胞对凋亡性中性粒细胞的吞噬作用。异二聚体结构包含α亚基(ITGAL)和β亚基(ITGB2)，其中α亚基与THBD相互作用。这种多方面的功能强调了整合素 α L β 2 在各种免疫和细胞过程中的不同作用。

Mouse

HEK293

C-His

P24063-1 (Y24-H1087)&P11835 (Q24-N702)

/&16414

160-180 kDa(ITGAL) & 90-105 kDa(ITGB2)

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.